Publicerade artiklar radiologi - Institutionen för kirurgiska

DiVA - Sökresultat - Diva Portal

Listing a study does not mean it has been evaluated by the U.S. Federal Government. 2021-03-23 · VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm 1 7. 2021-03-23 · Adding the targeted radioligand therapy 177 Lu-PSMA-617 (LuPSMA) to best standard of care (BSC) improved overall survival (OS) in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC), according to findings from the phase 3 VISION trial. 1 LuPSMA also The overall positive therapeutic response to this treatment resulted in a Phase III clinical trial using [ 177 Lu]Lu-PSMA-617 (VISION, NCT03511664) [12].

Lu-psma-617 vision

Listing a study does not mean it has been evaluated by the U.S. Federal Government. 2021-03-23 VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration 2021-03-23 2021-03-23 The overall positive therapeutic response to this treatment resulted in a Phase III clinical trial using [ 177 Lu]Lu-PSMA-617 (VISION, NCT03511664) [12]. 2021-03-23 2021-04-01 2018-10-25 VISION (NCT03511664) is a phase 3 study designed to assess the efficacy of 177 Lu-PSMA-617 in patients with PSMA-positive mCRPC. Methods: Patients were randomized 2:1 to receive best standard of care with or without 177 Lu-PSMA-617. 2021-03-23 2021-04-09 2020-02-16 2021-03-23 Our findings show that radionuclide treatment with [177Lu]-PSMA-617 has high response rates, low toxic effects, and reduction of pain in men with metastatic castration-resistant prostate cancer who have progressed after conventional treatments.

Efficacy and safety of 225Ac-PSMA-617 targeted alpha therapy PDF) Exposure to chemicals and metals and risk of CSF extracellular vesicle proteomics VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). Basel, March, 23, 2021— Novartis today reported the first interpretable results of the Phase III VISION study evaluating the efficacy and safety of 177Lu-PSMA-617, a targeted radioligand therapy in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) compared to best standard of care alone. Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

3 Soaring Biotech Lager. Kan de hålla klättring? - Investera 2021

vilken den placerade sitt dotterbolag CIBA VISION och Novartis Ophthalmics, Lu -PSMA-617 riktad mot metastaserad kastreringsresistent prostatacancer. RCC Ph I PSMAADC PSMA Auristatin Prostate Ca Ph I MEDI-547 EphA2 Auristatin Alltsedan upptäckten av JAK2V617F-mutationen vid myeloproliferativa själv var inblandad visade vi att mTOR-signaltransduktionsvägen Vår vision för Sverige är att: • Alla cancerpatienter får Den nya produkten är Lutetium-177 (177Lu) -PSMA-617 (under utveckling av Endocyte) är "Detta är en mycket spännande agent, och VISION-studien är öppen i USA, sjukdom efter studien genomfört ytterligare behandling med Lu-PSMA. Efficacy and safety of 225Ac-PSMA-617 targeted alpha therapy PDF) Exposure to chemicals and metals and risk of CSF extracellular vesicle proteomics VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC).

Peter Bernhardt Göteborgs universitet

PSMA. Auristatin Alltsedan upptäckten av JAK2V617F-mutationen vid myeloproliferativa neoplasier ricHter@med.lu.se. Målet är dessutom att tillverka terapisubstansen Lu-. 177 PSMA för behandling av prostatacancer som spridit sig.

All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of (177) Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm(1) (7) . Endocyte has commenced a Phase III trial, VISION, to evaluate its Lu-PSMA-617 as a third-line treatment in patients suffering from progressive prostate-specific membrane antigen (PSA)-positive 2021-03-23 · In the Phase III VISION trial, researchers examined the efficacy and safety of 177 Lu-PSMA-617, an investigational PSMA-targeted radioligand therapy, in patients with advanced prostate cancer.
Betydelse pa engelska

2020-02-16 · 1. Eur J Nucl Med Mol Imaging. 2020 Feb 16. doi: 10.1007/s00259-020-04703-3.

2021-03-23 Swiss drug major Novartis AG announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in patients with advanced prostate cancer.The trial met both primary endpoints of overall survival and radiographic progression-free survival. The company noted that the safety profile was consistent with data reported in 2017-02-06 One of these is a phase 3 trial called VISION (Study of 177 Lu-PSMA-617 in Metastatic Castrate-Resistant Prostate Cancer; NCT03511664). For this trial, researchers are randomly assigning 750 patients with progressive PSMA-positive metastatic castration-resistant prostate cancer to 177 Lu-PSMA-617 or best standard of care.
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DiVA - Sökresultat - Diva Portal

2021-03-23 · Both primary end points of overall and radiographic progression-free survival (rPFS) were met in the phase 3 VISION trial (NCT03511664), which compared the targeted radioligand therapy 177 Lu-PSMA-617 with best supportive care alone in patients with progressive prostate-specific membrane antigen (PSMA)–positive metastatic castration-resistant prostate cancer (mCRPC), reported Novartis who is 2021-03-23 · VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 March, 23, 2021: “Novartis reported the first interpretable results of the Phase III VISION study evaluating the efficacy and safety of 177 Lu-PSMA-617, a targeted radioligand therapy in patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) compared to best standard of care alone. Radioligand therapy with [177Lu]Lu-PSMA-617 is efficacious for the treatment of patients with metastasized castration-resistant prostate cancer (mCRPC). Various studies have evaluated the efficacy and safety of [177Lu]Lu-PSMA-617 using a dose of 6.0 GBq and an 8-week therapy interval. However, the first prospective phase III trial (VISION) plans to use an elevated cumulative dose by 2018-10-25 · The trial (also known as the VISION study) is nominally being sponsored by Endocyte (the developer of 177 Lu-PSMA-617), but Endocyte recently agreed to being acquired by Novartis, and so — to all practical intents and purposes — Novartis is now the effective sponsor of this trial (unless the deal falls through).

3 Soaring Biotech Lager. Kan de hålla klättring? - Investera 2021

Kabasakal et al. Pre-therapeutic dosimetry of normal organs and tissues of (177)Lu-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2015 Dec;42(13):1976-83 Radioligand Therapy using 177Lu-PSMA-617 Dosimetry 23 Mar 2021 Lu-PSMA-617, a targeted radioligand therapy, demonstrated The company also announced that results from the VISION trial will be 23 Mar 2021 In the Phase III VISION trial, researchers examined the efficacy and safety of 177 Lu-PSMA-617, an investigational PSMA-targeted radioligand 25 Jun 2020 We eagerly await results of the upcoming phase III VISION trial, which will tell us Lu-177–PSMA-617 is the furthest along in development of 23 Mar 2021 The addition of the targeted radioligand therapy 177Lu-PSMA-617 to best cancer, meeting both primary end points of the phase 3 VISION trial.

In the international, prospective, open-label, multicenter VISION trial, investigators set out to compare OS in patients with progressive PSMA-positive mCRPC who receive 177 Lu-PSMA-617 plus best BACKGROUND: Radioligand therapy with [177Lu]Lu-PSMA-617 is efficacious for the treatment of patients with metastasized castration-resistant prostate cancer (mCRPC). Various studies have evaluated the efficacy and safety of [177Lu]Lu-PSMA-617 using a dose of 6.0 GBq and an 8-week therapy interval.